Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
FunctionIn the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
Tissue specificityBrain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.
Sequence similaritiesBelongs to the GDA1/CD39 NTPase family.
Western blot - ENTPD2 antibody [EPR3885] (ab110711)
All lanes : Anti-ENTPD2 antibody [EPR3885] (ab110711) at 1/1000 dilution
Lane 1 : Human placenta cell lysate Lane 2 : JAR cell lysate Lane 3 : Human fetal kidney cell lysate Lane 4 : U-87MG cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size : 54 kDa
References for Anti-ENTPD2 antibody [EPR3885] (ab110711)
This product has been referenced in:
Visovatti SH et al. Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension. PLoS One7:e40829 (2012).
Read more (PubMed: 22792409) »