• Product name
  • Description
    Rabbit polyclonal to EPB41
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 107 - 156 (EKGEGGQKEI EFGTSLDEEI ILKAPIAAPE PELKTDPSLD LHSLSSAETQ) of Human EPB41 (NP_976218; UniProt ID: P11171 isoform 5).

  • Positive control
    • Human fetal spleen lysate



Our Abpromise guarantee covers the use of ab98854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: for isoform 5, 87 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
  • Involvement in disease
    Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
  • Sequence similarities
    Contains 1 FERM domain.
  • Post-translational
    Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
    Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
    O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
  • Cellular localization
    Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4.1R antibody
    • 41_HUMAN antibody
    • Band 4.1 antibody
    • E41P antibody
    • EL 1 antibody
    • EL1 antibody
    • EL1 gene antibody
    • Elliptocytosis 1 antibody
    • Elliptocytosis 1 RH linked antibody
    • EPB 4.1 antibody
    • EPB 41 antibody
    • EPB4.1 antibody
    • Epb41 antibody
    • Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody
    • Erythrocyte membrane protein band 4.1 antibody
    • Erythrocyte surface protein band 4.1 antibody
    • HE antibody
    • P4.1 antibody
    • Protein 4.1 antibody
    • Protein 4.1, red blood cell type antibody
    see all

Anti-EPB41 antibody images

  • Anti-EPB41 antibody (ab98854) at 1 µg/ml + Human fetal spleen lysate at 10 µg

    Predicted band size : for isoform 5, 87 kDa

References for Anti-EPB41 antibody (ab98854)

ab98854 has not yet been referenced specifically in any publications.

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