Overview

  • Product nameAnti-EPB42 antibody
    See all EPB42 primary antibodies
  • Description
    Rabbit polyclonal to EPB42
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 448-497 (ISTKGVGSDR CEDITQNYKY PEGSLQEKEV LERVEKEKME REKDNGIRPP) of Human EPB42 (NP_000110).

  • Positive control
    • Fetal liver lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab105076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 80 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionProbably plays an important role in the regulation of erythrocyte shape and mechanical properties.
  • Involvement in diseaseDefects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
  • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
  • Post-translational
    modifications
    Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
  • Cellular localizationCell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.
  • Information by UniProt
  • Database links
  • Alternative names
    • EPB42 antibody
    • EPB42_HUMAN antibody
    • Erythrocyte membrane protein band 4.2 antibody
    • Erythrocyte protein 4.2 antibody
    • Erythrocyte surface protein band 4.2 antibody
    • MGC116735 antibody
    • MGC116737 antibody
    • P4.2 antibody
    • PA antibody
    • SPH5 antibody
    see all

Anti-EPB42 antibody images

  • Anti-EPB42 antibody (ab105076) at 5 µg/ml + Human fetal liver lysate at 10 µg

    Predicted band size : 80 kDa

References for Anti-EPB42 antibody (ab105076)

ab105076 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"