Overview

  • Product name
  • Description
    Rabbit polyclonal to EPCR/CD201
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Pig, Common marmoset
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human EPCR/CD201.

    (Peptide available as ab88138.)

  • Positive control
    • This antibody gave a positive signal in the following tissue lysates: Human Heart; Human Lung.

Properties

Applications

Our Abpromise guarantee covers the use of ab78280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 27 kDa).

Target

  • Function
    Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
  • Tissue specificity
    Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
  • Post-translational
    modifications
    N-glycosylated.
    A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activated protein C receptor antibody
    • APC receptor antibody
    • APCR antibody
    • bA42O4.2 antibody
    • CCCA antibody
    • CCD41 antibody
    • CD201 antibody
    • CD201 antigen antibody
    • cell cycle, centrosome-associated protein antibody
    • Cell cycle, centrosome-associated protein antibody
    • centrocyclin antibody
    • Endothelial cell protein C receptor antibody
    • Endothelial protein C receptor antibody
    • EPCR antibody
    • EPCR_HUMAN antibody
    • MGC23024 antibody
    • PROCR antibody
    • Protein C receptor, endothelial antibody
    see all

Images

  • All lanes : Anti-EPCR/CD201 antibody (ab78280) at 1 µg/ml

    Lane 1 : Human heart tissue lysate - total protein (ab29431)
    Lane 2 : Lung (Human) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 27 kDa
    Observed band size : 24 kDa (why is the actual band size different from the predicted?)


    Exposure time : 14 minutes

References

ab78280 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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