Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Immunogen affinity purified
ab73255 was produced from a hybridoma (mouse myeloma fused with
spleen cells from a rat immunized with recombinant mouse Eph receptor A3 extracellular domain.
The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 µm filtered solution,
Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
Widely expressed. Highest level in placenta.
Involvement in disease
Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.