General notesab94111 is a 293T cell transfected lysate in which Human Eph receptor A3 has been transiently over-expressed using a pCMV-Eph receptor A3 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
Tissue specificity: Widely expressed. Highest level in placenta.
Disease: Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.