Purification notesab73256 was produced from a hybridoma (mouse myeloma fused with
spleen cells from a rat immunized with recombinant mouse Eph receptor A4 extracellular domain.
The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 µm filtered solution
FunctionReceptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.
DomainThe protein kinase domain mediates interaction with NGEF/ephexin-1.