• Product nameAnti-Eph receptor B2 antibody
    See all Eph receptor B2 primary antibodies
  • Description
    Goat polyclonal to Eph receptor B2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Xenopus laevis
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 864-875 of Human Eph receptor B2

  • Positive control
    • Human Lung and Placenta lysates.



Our Abpromise guarantee covers the use of ab58592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 117 kDa).


  • FunctionReceptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor.
  • Tissue specificityBrain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
  • Involvement in diseaseDefects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • cek5 antibody
    • Developmentally regulated EPH related tyrosine kinase antibody
    • DRT antibody
    • EK5 antibody
    • ELK related protein tyrosine kinase antibody
    • Eph receptor B2 antibody
    • EPH tyrosine kinase 3 antibody
    • EPH-like kinase 5 antibody
    • EPHB2 antibody
    • EPHB2_HUMAN antibody
    • Ephrin type B receptor 2 antibody
    • Ephrin type-B receptor 2 antibody
    • EPHT 3 antibody
    • ERK antibody
    • ETECK antibody
    • hEK5 antibody
    • Nuk antibody
    • Prkm 5 antibody
    • Receptor protein tyrosine kinase HEK 5 antibody
    • Renal carcinoma antigen NY-REN-47 antibody
    • Sek 3 antibody
    • Tyro 5 antibody
    • Tyrosine protein kinase receptor CEK 5 antibody
    • Tyrosine protein kinase receptor EPH 3 antibody
    • Tyrosine protein kinase receptor QEK 5 antibody
    • Tyrosine-protein kinase receptor EPH-3 antibody
    • Tyrosine-protein kinase TYRO5 antibody
    see all

Anti-Eph receptor B2 antibody images

References for Anti-Eph receptor B2 antibody (ab58592)

ab58592 has not yet been referenced specifically in any publications.

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