Anti-Eph receptor B6 antibody [RM0057-9B17] (ab73260)


  • Product name
    Anti-Eph receptor B6 antibody [RM0057-9B17]
    See all Eph receptor B6 primary antibodies
  • Description
    Rat monoclonal [RM0057-9B17] to Eph receptor B6
  • Specificity
    ab73260 is specific for mouse Eph receptor B6. It does not cross-react with recombinant mouse EphA2, EphA3, EphA4, EphA6, EphA7 EphA8, EphB2, EphB3, and EphB4
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant mouse Eph receptor B6 extracellular domain



Our Abpromise guarantee covers the use of ab73260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 110 kDa.
IHC-P 1/50 - 1/200.


  • Function
    Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
  • Tissue specificity
    Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Domain
    The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.
  • Post-translational
    Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
  • Cellular localization
    Secreted and Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EPH receptor B6 antibody
    • Ephb6 antibody
    • EPHB6_HUMAN antibody
    • Ephrin type B receptor 6 precursor antibody
    • Ephrin type-B receptor 6 antibody
    • HEP antibody
    • MGC129910 antibody
    • MGC129911 antibody
    • Tyrosine protein kinase defective receptor EPH 6 antibody
    • Tyrosine-protein kinase-defective receptor EPH-6 antibody
    see all


  • ab73260 at 1/200 dilution, staining Eph receptor B6 in LPS treated mouse kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).


ab73260 has not yet been referenced specifically in any publications.

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