Overview

  • Product nameAnti-Ephrin A1 antibody
    See all Ephrin A1 primary antibodies
  • Description
    Goat polyclonal to Ephrin A1
  • Specificityab109581 is expected to recognize isoform a (NP_004419.2) only.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Dog, Human, Pig
  • Immunogen

    Synthetic peptide:

    C-KVTVSGKITHSP

    , corresponding to internal sequence amino acids 144-155 of Human Ephrin A1 (NP_004419.2).

  • Positive control
    • Mouse Thymus and Rat Lung lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab109581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 24 kDa.

Target

  • FunctionPlays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
  • Tissue specificityBrain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
  • Sequence similaritiesBelongs to the ephrin family.
  • Post-translational
    modifications
    Undergo proteolysis by a metalloprotease to give rise to a soluble monomeric form.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • B61 antibody
    • ECKLG antibody
    • EFL 1 antibody
    • EFL1 antibody
    • EFNA 1 antibody
    • Efna1 antibody
    • EFNA1_HUMAN antibody
    • EPH related receptor tyrosine kinase ligand 1 antibody
    • EPH-related receptor tyrosine kinase ligand 1 antibody
    • Ephrin-A1 antibody
    • Ephrin-A1, secreted form antibody
    • EphrinA1 antibody
    • EPLG 1 antibody
    • EPLG1 antibody
    • Immediate early response protein B61 antibody
    • LERK 1 antibody
    • LERK-1 antibody
    • LERK1 antibody
    • Ligand of eph related kinase 1 antibody
    • OTTHUMP00000033242 antibody
    • OTTHUMP00000033271 antibody
    • secreted form antibody
    • TNF alpha-induced protein 4 antibody
    • TNFAIP 4 antibody
    • TNFAIP4 antibody
    • Tumor necrosis factor alpha induced protein 4 antibody
    • Tumor necrosis factor alpha-induced protein 4 antibody
    see all

Anti-Ephrin A1 antibody images

  • Anti-Ephrin A1 antibody (ab109581) at 0.01 µg/ml + Mouse Thymus lysate (in RIPA buffer) at 35 µg

    Predicted band size : 24 kDa

References for Anti-Ephrin A1 antibody (ab109581)

ab109581 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109581.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"