Anti-Ephrin A1 antibody [EPR1785(2)] (ab124911)


  • Product nameAnti-Ephrin A1 antibody [EPR1785(2)]
    See all Ephrin A1 primary antibodies
  • Description
    Rabbit monoclonal [EPR1785(2)] to Ephrin A1
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide from the N terminal region of Human Ephrin A1.

  • Positive control
    • HUVEC (treated with TNF alpha), HUVEC (untreated) and MCF7 cell lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.


Associated products


Our Abpromise guarantee covers the use of ab124911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa).
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionPlays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
    • Tissue specificityBrain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
    • Sequence similaritiesBelongs to the ephrin family.
    • Post-translational
      Undergo proteolysis by a metalloprotease to give rise to a soluble monomeric form.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • B61 antibody
      • ECKLG antibody
      • EFL 1 antibody
      • EFL1 antibody
      • EFNA 1 antibody
      • Efna1 antibody
      • EFNA1_HUMAN antibody
      • EPH related receptor tyrosine kinase ligand 1 antibody
      • EPH-related receptor tyrosine kinase ligand 1 antibody
      • Ephrin-A1 antibody
      • Ephrin-A1, secreted form antibody
      • EphrinA1 antibody
      • EPLG 1 antibody
      • EPLG1 antibody
      • Immediate early response protein B61 antibody
      • LERK 1 antibody
      • LERK-1 antibody
      • LERK1 antibody
      • Ligand of eph related kinase 1 antibody
      • OTTHUMP00000033242 antibody
      • OTTHUMP00000033271 antibody
      • secreted form antibody
      • TNF alpha-induced protein 4 antibody
      • TNFAIP 4 antibody
      • TNFAIP4 antibody
      • Tumor necrosis factor alpha induced protein 4 antibody
      • Tumor necrosis factor alpha-induced protein 4 antibody
      see all

    Anti-Ephrin A1 antibody [EPR1785(2)] images

    • All lanes : Anti-Ephrin A1 antibody [EPR1785(2)] (ab124911) at 1/1000 dilution

      Lane 1 : HUVEC cell lysate, treated with TNF alpha
      Lane 2 : HUVEC cell lysate
      Lane 3 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 24 kDa
      Observed band size : 24 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References for Anti-Ephrin A1 antibody [EPR1785(2)] (ab124911)

    ab124911 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab124911.
    Please use the links above to contact us or submit feedback about this product.