Overview

  • Product name
  • Description
    Rabbit polyclonal to Ephrin B1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 179-228 (SRPSKEADNT VKMATQAPGS RGSLGDSDGK HETVNQEEKS GPGASGGSSG) of Human Ephrin B1 (NP_004420).

  • Positive control
    • Human fetal kidney lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
  • Tissue specificity
    Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.
  • Involvement in disease
    Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies.
  • Sequence similarities
    Belongs to the ephrin family.
  • Post-translational
    modifications
    Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CFND antibody
    • CFNS antibody
    • Craniofrontonasal syndrome (craniofrontonasal dysplasia) antibody
    • EFL 3 antibody
    • EFL-3 antibody
    • EFL3 antibody
    • EFNB1 antibody
    • EFNB1_HUMAN antibody
    • Elk L antibody
    • ELK ligand antibody
    • ELK-L antibody
    • Eph related receptor tyrosine kinase ligand 2 antibody
    • EPH-related receptor tyrosine kinase ligand 2 antibody
    • Ephrin-B1 antibody
    • EPLG2 antibody
    • LERK 2 antibody
    • LERK-2 antibody
    • LERK2 antibody
    • Ligand of eph related kinase 2 antibody
    • MGC8782 antibody
    see all

Images

  • Anti-Ephrin B1 antibody (ab99029) at 1 µg/ml + Human fetal kidney lysate at 10 µg
    Developed using the ECL technique

    Predicted band size : 38 kDa

References

ab99029 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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