Anti-Ephrin B1 (phospho Y331) antibody (ab30563)

Overview

  • Product nameAnti-Ephrin B1 (phospho Y331) antibody
    See all Ephrin B1 primary antibodies
  • Description
    Rabbit polyclonal to Ephrin B1 (phospho Y331)
  • Specificityab30563 recognises EphB1 (phospho Y331).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Chicken, Cow, Human, Xenopus laevis, Zebrafish
  • Immunogen

    Synthetic Phosphopeptide corresponding to amino acid residues surrounding the phospho Tyr331 of chicken Ephrin B1. Note: Chicken Tyr331 is the homolog of mouse and rat Tyr343, human Tyr344 and also Xenopus Tyr324.

  • Positive control
    • Rat Testes Lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab30563 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 46 - 50 kDa.

Target

  • FunctionBinds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
  • Tissue specificityHeart, placenta, lung, liver, skeletal muscle, kidney, pancreas.
  • Involvement in diseaseDefects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies.
  • Sequence similaritiesBelongs to the ephrin family.
  • Post-translational
    modifications
    Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CFND antibody
    • CFNS antibody
    • Craniofrontonasal syndrome (craniofrontonasal dysplasia) antibody
    • EFL 3 antibody
    • EFL-3 antibody
    • EFL3 antibody
    • EFNB1 antibody
    • EFNB1_HUMAN antibody
    • Elk L antibody
    • ELK ligand antibody
    • ELK-L antibody
    • Eph related receptor tyrosine kinase ligand 2 antibody
    • EPH-related receptor tyrosine kinase ligand 2 antibody
    • Ephrin-B1 antibody
    • EPLG2 antibody
    • LERK 2 antibody
    • LERK-2 antibody
    • LERK2 antibody
    • Ligand of eph related kinase 2 antibody
    • MGC8782 antibody
    see all

Anti-Ephrin B1 (phospho Y331) antibody images

  • All lanes : Anti-Ephrin B1 (phospho Y331) antibody (ab30563)

    Lane 1 : rat testes
    Lane 2 : rat testes, treated with lambda-phosphatase


    Predicted band size : 46 - 50 kDa


    Western blot of rat testes lysate showing specific immunolabeling of the ~46 kDa EphrinB1 phosphorylated at Tyr331 (control, lane 1). The phospho-specificity of this labeling is shown in lane 2 (identical blot, except for incubation with lambda-phosphatase (1200 units for 30 min) before exposure to the anti-Tyr331 ephrinB antibody). The immunolabeling is completely eliminated by treatment with lambda-phosphatase.

References for Anti-Ephrin B1 (phospho Y331) antibody (ab30563)

ab30563 has not yet been referenced specifically in any publications.

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