Overview

  • Product nameAnti-Ephrin B2 antibody
    See all Ephrin B2 primary antibodies
  • Description
    Goat polyclonal to Ephrin B2
  • SpecificityThe antibody will recognize recombinant mouse Ephrin-B2 by immunoblotting and ELISA. By immunoblotting and ELISA, the antibody shows approximately 50% cross-reactivity with recombinant human Ephrin-A5 and 15% cross-reactivity with mouse Ephrin-B1.
  • Tested applicationsSuitable for: IHC-Fr, Indirect ELISA, WBmore details
    Unsuitable for: ICC/IF
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant full length protein (Mouse). Expressed in NSO cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab7043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent dilution.
Indirect ELISA Use a concentration of 0.1 - 0.2 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml.
  • Application notesIs unsuitable for ICC/IF.
  • Target

    • FunctionCell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
      (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
    • Tissue specificityLung and kidney.
    • Sequence similaritiesBelongs to the ephrin family.
      Contains 1 ephrin RBD (ephrin receptor-binding) domain.
    • Post-translational
      modifications
      Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • EFN B2 antibody
      • EFNB 2 antibody
      • Efnb2 antibody
      • EFNB2_HUMAN antibody
      • Eph related receptor tyrosine kinase ligand 5 antibody
      • EPH-related receptor tyrosine kinase ligand 5 antibody
      • ephrin B2 antibody
      • Ephrin-B2 antibody
      • EphrinB2 antibody
      • EPLG 5 antibody
      • EPLG5 antibody
      • Htk L antibody
      • HTK ligand antibody
      • HTK-L antibody
      • HTKL antibody
      • LERK 5 antibody
      • LERK-5 antibody
      • LERK5 antibody
      • Ligand of eph related kinase 5 antibody
      • MGC126226 antibody
      • MGC126227 antibody
      • MGC126228 antibody
      • OTTMUSP00000024973 antibody
      see all

    References for Anti-Ephrin B2 antibody (ab7043)

    ab7043 has not yet been referenced specifically in any publications.

    Product Wall

    We develop many of our antibodies in-house, while others are sourced from select suppliers with whom we have very strict non-disclosure agreements. This product falls into the latter category.

    This antibody has not been tested for cross-reactivity with human Ephrin B2

    The antibody should be useful in immunohistochemistry since it is a polyclonal raised against the whole molecule and therefore would recognise multiple epitopes. If you order and find that it does not work, in exchange for your negative data (which we ...

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    In general, antibodies raised against recombinant proteins give excellent IP results due to multiple and diverse epitopes. However, although it is likely to work, we do not yet have any data. Please let us know your results if you decide to use the ant...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"