Anti-epithelial Sodium Channel gamma antibody (ab115272)

Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab115272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionSodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • Involvement in diseaseDefects in SCNN1G are a cause of Liddle syndrome (LIDDS) [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
    Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3) [MIM:613071]. A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases.
  • Sequence similaritiesBelongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
  • Post-translational
    modifications
    Phosphorylated on serine and threonine residues.
    Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.
  • Cellular localizationApical cell membrane. Apical membrane of epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amiloride sensitive epithelial sodium channel gamma subunit antibody
    • Amiloride sensitive sodium channel subunit gamma antibody
    • Amiloride-sensitive sodium channel subunit gamma antibody
    • BESC3 antibody
    • ENaC gamma subunit antibody
    • ENaCG antibody
    • ENaCgamma antibody
    • Epithelial Na(+) channel subunit gamma antibody
    • Epithelial Na+ channel subunit gamma antibody
    • Gamma ENaC antibody
    • Gamma NaCH antibody
    • Gamma-ENaC antibody
    • Gamma-NaCH antibody
    • Nonvoltage gated sodium channel 1 subunit gamma antibody
    • Nonvoltage-gated sodium channel 1 subunit gamma antibody
    • PHA 1 antibody
    • PHA1 antibody
    • SCNEG antibody
    • SCNN 1G antibody
    • SCNN1G antibody
    • SCNNG_HUMAN antibody
    • Sodium channel non voltage gated 1 gamma subunit antibody
    • Sodium channel nonvoltage gated 1 gamma antibody
    see all

Anti-epithelial Sodium Channel gamma antibody images

  • Human colon (formalin fixed, paraffin embedded) tissue stained with ab115272 at 4 µg/ml by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated anti-goat IgG secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

References for Anti-epithelial Sodium Channel gamma antibody (ab115272)

ab115272 has not yet been referenced specifically in any publications.

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