• Product name
  • Description
    Rabbit polyclonal to EPM2A
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human) from the C-terminal region conjugated to KLH

  • Positive control
    • Human skeletal muscle tissue



Our Abpromise guarantee covers the use of ab70904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).
ELISA 1/1000.
IHC-P 1/10 - 1/50.


  • Function
    Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.
  • Tissue specificity
    Expressed in heart, skeletal muscle, kidney, pancreas and brain. Isoform 4 is also expressed in the placenta.
  • Involvement in disease
    Defects in EPM2A are a cause of progressive myoclonic epilepsy type 2 (EPM2) [MIM:254780]; also known as Lafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Typically, as seizures increase in frequency, cognitive function declines towards dementia, and affected individuals die usually within 10 years after onset. EPM2 occurs worldwide, but it is particularly common in the mediterranean countries of southern Europe and northern Africa, in southern India and in the Middle East. At the cellular level, it is characterized by accumulation of starch-like polyglucosans called Lafora bodies (LBs) that are most abundant in organs with the highest glucose metabolism: brain, heart, liver and skeletal muscle. Among other conditions involving polyglucosans, EPM2 is unique in that the inclusions are in neuronal dendrites but not axons and the forming polyglucosan fibrils are associated with the endoplasmic reticulum.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 CBM20 (carbohydrate binding type-20) domain.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    Polyubiquitinated by NHLRC1/malin.
    Phosphorylation on Ser-25 by AMPK affects the phosphatase activity of the enzyme and its ability to homodimerize and interact with NHLRC1, PPP1R3C or PRKAA2.
  • Cellular localization
    Cytoplasm; Cytoplasm. Nucleus; Endoplasmic reticulum. Cell membrane. Nucleus. Also found in the nucleus; Endoplasmic reticulum. Cell membrane. Primarily associated with polyribosomes at the endoplasmic reticulum, also found at the plasma membrane and Cytoplasm. Under glycogenolytic conditions localizes to the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Epilepsy progressive myoclonus type 2 Lafora disease (laforin) antibody
    • Epilepsy progressive myoclonus type 2A Lafora disease (laforin) antibody
    • EPM2 antibody
    • Epm2a antibody
    • Epm2a gene antibody
    • EPM2A_HUMAN antibody
    • Lafora PTPase antibody
    • Laforin antibody
    • LAFPTPase antibody
    • LD antibody
    • LDE antibody
    • MELF antibody
    • RP3-466P17.2 antibody
    see all


  • All lanes : Anti-EPM2A antibody (ab70904) at 1/50 dilution

    Lane 1 : Non transfected 293 cell lysate
    Lane 2 : EPM2A transfected 293 cell lysate

    Lysates/proteins at 2 µg per lane.

    Predicted band size : 37 kDa
    Observed band size : 37 kDa
    Additional bands at : 90 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human skeletal muscle tissue labelled with ab70904 at 1/10 dilution followed by peroxidase conjugation to the secondary antibody and DAB staining.


ab70904 has not yet been referenced specifically in any publications.

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