Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.
Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
Belongs to the EPS8 family. Contains 1 PH domain. Contains 1 SH3 domain.
The SH3 domain mediates interaction with SHB.
Phosphorylated by several receptor tyrosine kinases.
Mok KW et al. Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network. FASEB J27:1137-52 (2013).
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Qian X et al. Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. Am J Physiol Endocrinol Metab304:E757-69 (2013).
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