FunctionPlays a role in the formation of clathrin-coated invaginations and endocytosis.
Tissue specificityHighest expression is found in brain. Detected at lower levels in lung and liver.
Sequence similaritiesBelongs to the epsin family. Contains 1 ENTH (epsin N-terminal homology) domain. Contains 2 UIM (ubiquitin-interacting motif) repeats.
DomainThe NPF repeat domain is involved in EPS15 binding. The DPW repeat domain is involved in AP-2 and clathrin binding.
Cellular localizationCytoplasm. Cytoplasmic vesicle > clathrin-coated vesicle. In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.