Overview

  • Product nameAnti-ERAB antibody [5F3]
    See all ERAB primary antibodies
  • Description
    Mouse monoclonal [5F3] to ERAB
  • SpecificityThis antibody detects the recombinant human ERAB protein (27kDa) and recognizes the endogenous ERAB protein in cell extracts with virtually no crossreactivity with other human proteins.
  • Tested applicationsSuitable for: WB, Dot blot, IHC-P, IHC-Fr, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant, full-length Human ERAB protein (fusion protein).

Properties

Applications

Our Abpromise guarantee covers the use of ab10260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Dot blot
IHC-P
IHC-Fr
ELISA
ICC/IF
  • Application notesDot: 1/100 - 1/10000.
    ELISA: Use at an assay dependent dilution.
    ICC/IF: Suggested working dilution of 1/2000 (see PMID: 17322883).
    IHC-P: 1/100 - 1/1000.
    IHC-Fr: 1/100 - 1/1000.
    WB: 1/100 - 1/10000. Predicted molecular weight: 27 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
    • Tissue specificityExpressed in normal tissues but is overexpressed in neurons affected in AD.
    • Involvement in diseaseDefects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
      Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
      A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.
    • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localizationMitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • 17 beta hydroxysteroid dehydrogenase 10 antibody
      • 17 beta hydroxysteroid dehydrogenase type 10 antibody
      • 17-beta-HSD 10 antibody
      • 17-beta-hydroxysteroid dehydrogenase 10 antibody
      • 17b HSD10 antibody
      • 3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody
      • 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • 3 hydroxyacyl CoA dehydrogenase type II antibody
      • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody
      • 3-hydroxyacyl-CoA dehydrogenase type II antibody
      • 3-hydroxyacyl-CoA dehydrogenase type-2 antibody
      • AB binding alcohol dehydrogenase antibody
      • ABAD antibody
      • Ads9 antibody
      • Amyloid beta binding polypeptide antibody
      • Amyloid beta peptide binding alcohol dehydrogenase antibody
      • Amyloid beta peptide binding protein antibody
      • Amyloid beta peptide binding protein antibody
      • CAMR antibody
      • DUPXp11.22 antibody
      • Endoplasmic Reticulum Amyloid Binding Protein antibody
      • Endoplasmic reticulum associated amyloid beta peptide binding protein antibody
      • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody
      • ER associated amyloid beta-binding protein antibody
      • ERAB antibody
      • HADH 2 antibody
      • HADH2 antibody
      • HCD 2 antibody
      • HCD2 antibody
      • HCD2_HUMAN antibody
      • Hsd17b10 antibody
      • Hydroxyacyl CoA Dehydrogenase type II antibody
      • Hydroxyacyl Coenzyme A dehydrogenase type II antibody
      • Hydroxysteroid (17 beta) dehydrogenase 10 antibody
      • Mental retardation X linked syndromic 11 antibody
      • MHBD antibody
      • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody
      • Mitochondrial ribonuclease P protein 2 antibody
      • Mitochondrial RNase P protein 2 antibody
      • MRPP2 antibody
      • MRX17 antibody
      • SCHAD antibody
      • SDR5C1 antibody
      • Short chain dehydrogenase/reductase family 5C member 1 antibody
      • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • Short chain type dehydrogenase/reductase XH98G2 antibody
      • Short-chain type dehydrogenase/reductase XH98G2 antibody
      • Type 10 17b HSD antibody
      • Type 10 17beta hydroxysteroid dehydrogenase antibody
      • Type II HADH antibody
      • XH98G2 antibody
      see all

    Anti-ERAB antibody [5F3] images

    • IF using ab10260.

    References for Anti-ERAB antibody [5F3] (ab10260)

    This product has been referenced in:
    • Onoguchi K  et al. Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. PLoS Pathog 6:e1001012 (2010). WB, ICC/IF ; Human . Read more (PubMed: 20661427) »
    • Stevanin G  et al. Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum. Nat Genet 39:366-372 (2007). Read more (PubMed: 17322883) »

    See all 2 Publications for this product

    Product Wall

    Thank you for your email. Unfortunately, we do not know the exact epitope that this product recognizes. We have not done an epitope mapping project for this yet. I apologize for the inconvenience.

    The application was added to the datasheet based on publication in the following reference:

    Stevanin G et al. Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum. Nat Genet 39:366-372 (20...

    Read More

    Thank you for your enquiry. I am sorry that unfortunately, we are unable to supply this anti-ERAB antibody (ab10260) without sodium azide. We do, however, have another anti-ERAB antibody available that contains no preservatives. This is a Mouse monoclo...

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    Thank you for your email. ERAB is identical to SCHAD. The following reference that I found explains this best: Characterization and localization of human type10 17-hydroxysteroid dehydrogenase; Eur. J. Biochem. 268, 4899-4907 (2001). In it the autho...

    Read More

    Unfortunately, we do not have more information about this antibody. We will update the on-line datasheet of this product as soon as we get more data. We apologize for any inconvenience caused.

    Unfortunately, we do not have more information about this antibody. We will update the on-line datasheet of this product as soon as we get more data. We apologize for any inconvenience caused. If you have any more questions, please do contact us again.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"