• Product nameAnti-ERAB antibody
    See all ERAB primary antibodies
  • Description
    Rabbit polyclonal to ERAB
  • Tested applicationsSuitable for: IHC-FoFr, WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    A 14 amino acid synthetic peptide sequence from the middle portion of ERAB (Human).



Our Abpromise guarantee covers the use of ab17297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: 1/10000 - 1/100000.
    IHC-FoFr: 1/100 (PMID 19279043).
    WB: 1/1000 - 1/5000. Detects a band of approximately 27 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
    • Tissue specificityExpressed in normal tissues but is overexpressed in neurons affected in AD.
    • Involvement in diseaseDefects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
      Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
      A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.
    • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localizationMitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • 17 beta hydroxysteroid dehydrogenase 10 antibody
      • 17 beta hydroxysteroid dehydrogenase type 10 antibody
      • 17-beta-HSD 10 antibody
      • 17-beta-hydroxysteroid dehydrogenase 10 antibody
      • 17b HSD10 antibody
      • 3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody
      • 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • 3 hydroxyacyl CoA dehydrogenase type II antibody
      • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody
      • 3-hydroxyacyl-CoA dehydrogenase type II antibody
      • 3-hydroxyacyl-CoA dehydrogenase type-2 antibody
      • AB binding alcohol dehydrogenase antibody
      • ABAD antibody
      • Ads9 antibody
      • Amyloid beta binding polypeptide antibody
      • Amyloid beta peptide binding alcohol dehydrogenase antibody
      • Amyloid beta peptide binding protein antibody
      • Amyloid beta peptide binding protein antibody
      • CAMR antibody
      • DUPXp11.22 antibody
      • Endoplasmic Reticulum Amyloid Binding Protein antibody
      • Endoplasmic reticulum associated amyloid beta peptide binding protein antibody
      • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody
      • ER associated amyloid beta-binding protein antibody
      • ERAB antibody
      • HADH 2 antibody
      • HADH2 antibody
      • HCD 2 antibody
      • HCD2 antibody
      • HCD2_HUMAN antibody
      • Hsd17b10 antibody
      • Hydroxyacyl CoA Dehydrogenase type II antibody
      • Hydroxyacyl Coenzyme A dehydrogenase type II antibody
      • Hydroxysteroid (17 beta) dehydrogenase 10 antibody
      • Mental retardation X linked syndromic 11 antibody
      • MHBD antibody
      • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody
      • Mitochondrial ribonuclease P protein 2 antibody
      • Mitochondrial RNase P protein 2 antibody
      • MRPP2 antibody
      • MRX17 antibody
      • SCHAD antibody
      • SDR5C1 antibody
      • Short chain dehydrogenase/reductase family 5C member 1 antibody
      • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • Short chain type dehydrogenase/reductase XH98G2 antibody
      • Short-chain type dehydrogenase/reductase XH98G2 antibody
      • Type 10 17b HSD antibody
      • Type 10 17beta hydroxysteroid dehydrogenase antibody
      • Type II HADH antibody
      • XH98G2 antibody
      see all

    References for Anti-ERAB antibody (ab17297)

    This product has been referenced in:
    • Yu Y  et al. Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Mol Cell Proteomics : (2009). WB, IHC-FoFr ; Mouse . Read more (PubMed: 19279043) »

    See 1 Publication for this product

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