Overview

  • Product name
  • Description
    Goat polyclonal to ERAB
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog, Xenopus laevis, Chimpanzee, Zebrafish
  • Immunogen

    Synthetic peptide:

    CIRLDGAIRMQP

    , corresponding to C terminal amino acids 250-261 of Human ERAB.

  • Positive control
    • Human Brain Lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab28750 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA: 1/32000.
    WB: Use at a concentration of 0.3 - 2.0 µg/ml. Detects a band of approximately 25 kDa. A minor band of unknown identity was also consistently observed at approximately 38kDa. This band was successfully blocked by incubation with the immunising peptide. (Predicted molecular weight: 26 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
    • Tissue specificity
      Expressed in normal tissues but is overexpressed in neurons affected in AD.
    • Involvement in disease
      Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
      Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
      A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.
    • Sequence similarities
      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization
      Mitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • 17 beta hydroxysteroid dehydrogenase 10 antibody
      • 17 beta hydroxysteroid dehydrogenase type 10 antibody
      • 17-beta-HSD 10 antibody
      • 17-beta-hydroxysteroid dehydrogenase 10 antibody
      • 17b HSD10 antibody
      • 3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody
      • 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • 3 hydroxyacyl CoA dehydrogenase type II antibody
      • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody
      • 3-hydroxyacyl-CoA dehydrogenase type II antibody
      • 3-hydroxyacyl-CoA dehydrogenase type-2 antibody
      • AB binding alcohol dehydrogenase antibody
      • ABAD antibody
      • Ads9 antibody
      • Amyloid beta binding polypeptide antibody
      • Amyloid beta peptide binding alcohol dehydrogenase antibody
      • Amyloid beta peptide binding protein antibody
      • Amyloid beta peptide binding protein antibody
      • CAMR antibody
      • DUPXp11.22 antibody
      • Endoplasmic Reticulum Amyloid Binding Protein antibody
      • Endoplasmic reticulum associated amyloid beta peptide binding protein antibody
      • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody
      • ER associated amyloid beta-binding protein antibody
      • ERAB antibody
      • HADH 2 antibody
      • HADH2 antibody
      • HCD 2 antibody
      • HCD2 antibody
      • HCD2_HUMAN antibody
      • Hsd17b10 antibody
      • Hydroxyacyl CoA Dehydrogenase type II antibody
      • Hydroxyacyl Coenzyme A dehydrogenase type II antibody
      • Hydroxysteroid (17 beta) dehydrogenase 10 antibody
      • Mental retardation X linked syndromic 11 antibody
      • MHBD antibody
      • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody
      • Mitochondrial ribonuclease P protein 2 antibody
      • Mitochondrial RNase P protein 2 antibody
      • MRPP2 antibody
      • MRX17 antibody
      • SCHAD antibody
      • SDR5C1 antibody
      • Short chain dehydrogenase/reductase family 5C member 1 antibody
      • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • Short chain type dehydrogenase/reductase XH98G2 antibody
      • Short-chain type dehydrogenase/reductase XH98G2 antibody
      • Type 10 17b HSD antibody
      • Type 10 17beta hydroxysteroid dehydrogenase antibody
      • Type II HADH antibody
      • XH98G2 antibody
      see all

    Images

    • Anti-ERAB antibody (ab28750) at 0.3 µg/ml + Human brain lysate (RIPA buffer, 30µg total protein per lane)
      Developed using the ECL technique

      Predicted band size : 26 kDa
      Observed band size : 25 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 38 kDa. We are unsure as to the identity of these extra bands.

    References

    ab28750 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab28750.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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