Anti-ERAB antibody [EPR11838(B)] (ab170864)


  • Product name
    Anti-ERAB antibody [EPR11838(B)]
    See all ERAB primary antibodies
  • Description
    Rabbit monoclonal [EPR11838(B)] to ERAB
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC/IF or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human ERAB.
    Database link: Q99714

  • Positive control
    • Human brain and uterus tissues. Jurkat, 293T, HeLa and K562 cell lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents



Our Abpromise guarantee covers the use of ab170864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 27 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IP.
  • Target

    • Function
      Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
    • Tissue specificity
      Expressed in normal tissues but is overexpressed in neurons affected in AD.
    • Involvement in disease
      Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
      Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
      A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.
    • Sequence similarities
      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • 17 beta hydroxysteroid dehydrogenase 10 antibody
      • 17 beta hydroxysteroid dehydrogenase type 10 antibody
      • 17-beta-HSD 10 antibody
      • 17-beta-hydroxysteroid dehydrogenase 10 antibody
      • 17b HSD10 antibody
      • 3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody
      • 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • 3 hydroxyacyl CoA dehydrogenase type II antibody
      • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody
      • 3-hydroxyacyl-CoA dehydrogenase type II antibody
      • 3-hydroxyacyl-CoA dehydrogenase type-2 antibody
      • AB binding alcohol dehydrogenase antibody
      • ABAD antibody
      • Ads9 antibody
      • Amyloid beta binding polypeptide antibody
      • Amyloid beta peptide binding alcohol dehydrogenase antibody
      • Amyloid beta peptide binding protein antibody
      • Amyloid beta peptide binding protein antibody
      • CAMR antibody
      • DUPXp11.22 antibody
      • Endoplasmic Reticulum Amyloid Binding Protein antibody
      • Endoplasmic reticulum associated amyloid beta peptide binding protein antibody
      • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody
      • ER associated amyloid beta-binding protein antibody
      • ERAB antibody
      • HADH 2 antibody
      • HADH2 antibody
      • HCD 2 antibody
      • HCD2 antibody
      • HCD2_HUMAN antibody
      • Hsd17b10 antibody
      • Hydroxyacyl CoA Dehydrogenase type II antibody
      • Hydroxyacyl Coenzyme A dehydrogenase type II antibody
      • Hydroxysteroid (17 beta) dehydrogenase 10 antibody
      • Mental retardation X linked syndromic 11 antibody
      • MHBD antibody
      • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody
      • Mitochondrial ribonuclease P protein 2 antibody
      • Mitochondrial RNase P protein 2 antibody
      • MRPP2 antibody
      • MRX17 antibody
      • SCHAD antibody
      • SDR5C1 antibody
      • Short chain dehydrogenase/reductase family 5C member 1 antibody
      • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody
      • Short chain type dehydrogenase/reductase XH98G2 antibody
      • Short-chain type dehydrogenase/reductase XH98G2 antibody
      • Type 10 17b HSD antibody
      • Type 10 17beta hydroxysteroid dehydrogenase antibody
      • Type II HADH antibody
      • XH98G2 antibody
      see all


    • ab170864 showing +ve staining in Human placenta tissue.

    • ab170864 showing +ve staining in Human thyroid gland carcinoma tissue.

    • ab170864 showing +ve staining in Human astrocytoma tissue.

    • ab170864 showing +ve staining in Human normal liver tissue.

    • Immunohistochemical analysis of Formalin-fixed paraffin-embedded Human uterus tissue labeling ERAB with ab170864 at 1/50 dilution.

    • Immunohistochemical analysis of Formalin-fixed paraffin-embedded Human brain tissue labeling ERAB with ab170864 at 1/50 dilution.

    • All lanes : Anti-ERAB antibody [EPR11838(B)] (ab170864) at 1/1000 dilution

      Lane 1 : Jurkat cell lysates
      Lane 2 : 293T cell lysates
      Lane 3 : HeLa cell lysates
      Lane 4 : K562 cell lysates

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 27 kDa


    ab170864 has not yet been referenced specifically in any publications.

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