Anti-ErbB 3 (phospho Y1289) antibody (ab62435)


  • Product nameAnti-ErbB 3 (phospho Y1289) antibody
    See all ErbB 3 primary antibodies
  • Description
    Rabbit polyclonal to ErbB 3 (phospho Y1289)
  • SpecificityThis antibody detects endogenous levels of HER3/ErbB3 only when phosphorylated at tyrosine 1289.
  • Tested applicationsSuitable for: ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic phosphopeptide derived from human ErbB3 around the phosphorylation site of tyrosine 1289 (Q-G-YP-E-E).

  • Positive control
    • HeLa cells



Our Abpromise guarantee covers the use of ab62435 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/500 - 1/1000.
ELISA 1/10000.


  • FunctionBinds and is activated by neuregulins and NTAK.
  • Tissue specificityEpithelial tissues and brain.
  • Involvement in diseaseDefects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
    Contains 1 protein kinase domain.
  • Developmental stageOverexpressed in a subset of human mammary tumors.
  • DomainThe cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
  • Post-translational
    Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • c erbB 3 antibody
    • c erbB3 antibody
    • Erb b2 receptor tyrosine kinase 3 antibody
    • ErbB 3 antibody
    • ERBB3 antibody
    • ERBB3 protein antibody
    • erbB3 S antibody
    • ERBB3_HUMAN antibody
    • Glial growth factor receptor antibody
    • HER 3 antibody
    • HER3 antibody
    • Human epidermal growth factor receptor 3 antibody
    • LCCS2 antibody
    • MDA BF 1 antibody
    • MGC88033 antibody
    • p180 ErbB3 antibody
    • p45 sErbB3 antibody
    • p85 sErbB3 antibody
    • proto-oncogene-like protein c ErbB 3 antibody
    • proto-oncogene-like protein c ErbB3 antibody
    • Proto-oncogene-like protein c-ErbB-3 antibody
    • Receptor tyrosine protein kinase erbB 3 antibody
    • Receptor tyrosine protein kinase erbB3 antibody
    • Receptor tyrosine-protein kinase erbB-3 antibody
    • Tyrosine kinase type cell surface receptor HER3 antibody
    • Tyrosine kinase-type cell surface receptor HER3 antibody
    • v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
    see all

Anti-ErbB 3 (phospho Y1289) antibody images

  • Immunofluorescent analysis of HeLa cells using ab62435 at a 1/500 dilution, in the presence (right) and absence (left) of immunising phosphopeptide.

References for Anti-ErbB 3 (phospho Y1289) antibody (ab62435)

ab62435 has not yet been referenced specifically in any publications.

Product Wall

-Note yet tested on frozen sections but has been tested on paraffin embedded sections
fixation methods: formalin
Recommended starting dilution: 1:50
Positive control: testis, brain
Negative control: protein is widely ex...

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