Overview

  • Product nameAnti-Erbin antibody
    See all Erbin primary antibodies
  • Description
    Rabbit polyclonal to Erbin
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to N-terminal residues of human ERBB2IP

Properties

Applications

Our Abpromise guarantee covers the use of ab55930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 157 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • FunctionActs as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.
  • Tissue specificityHighly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
  • Sequence similaritiesBelongs to the LAP (LRR and PDZ) protein family.
    Contains 17 LRR (leucine-rich) repeats.
    Contains 1 PDZ (DHR) domain.
  • Cellular localizationCell junction > hemidesmosome. Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Densin-180-like protein antibody
    • Erbb2-interacting protein antibody
    • Erbb2ip antibody
    • Erbin antibody
    • LAP2 antibody
    • LAP2_HUMAN antibody
    • Protein LAP2 antibody
    see all

Anti-Erbin antibody images

  • All lanes : Anti-Erbin antibody (ab55930) at 1 µg/ml

    Lane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
    Lane 2 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Predicted band size : 157 kDa
    Observed band size : 172 kDa (why is the actual band size different from the predicted?)

References for Anti-Erbin antibody (ab55930)

This product has been referenced in:
  • Pan P & Dobrowsky RT Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. Acta Neuropathol Commun 1:39 (2013). Mouse . Read more (PubMed: 24252174) »
  • Lipinski S  et al. RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition. Proc Natl Acad Sci U S A : (2012). Read more (PubMed: 23213202) »

See all 2 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"