Overview

  • Product nameAnti-ERC1 antibody
    See all ERC1 primary antibodies
  • Description
    Goat polyclonal to ERC1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    YGSARSVGKVEPS

    , corresponding to N terminal amino acids 2-14 of Human ELKS.

  • Positive control
    • Human Pancreas and Testis lysates

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab21192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 37, 85 kDa.Can be blocked with Human ERC1 peptide (ab45484).

Target

  • FunctionRegulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • Tissue specificityWidely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • Involvement in diseaseThyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving ERC1/RAB6IP2 is found in cause of thyroid papillary carcinomas. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • Sequence similaritiesContains 1 FIP-RBD domain.
  • Cellular localizationCytoplasm. Membrane. Golgi apparatus membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cast 2 antibody
    • CAST2 antibody
    • CAZ associated structural protein 2 antibody
    • Elks antibody
    • ELKS/RAB6 interacting/CAST family member 1 antibody
    • ELKS/RAB6-interacting/CAST family member 1 antibody
    • ERC 1 antibody
    • ERC protein 1 antibody
    • ERC-1 antibody
    • Erc1 antibody
    • ERC1 protein antibody
    • KIAA1081 antibody
    • MGC12974 antibody
    • RAB6 interacting protein 2 antibody
    • RAB6-interacting protein 2 antibody
    • RAB6IP2 antibody
    • RB6I2_HUMAN antibody
    see all

Anti-ERC1 antibody images

  • Anti-ERC1 antibody (ab21192) at 0.1 µg/ml + Tissue lysates prepared from human pancreas at 35 µg

References for Anti-ERC1 antibody (ab21192)

ab21192 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Unfortunately, we haven't tested it throughly outside pancreas and testis so no we have no other positive controls. You might find something else by looking in the literature. I hope that this information helps. Please d...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"