Overview

  • Product nameAnti-ERC1 antibody
    See all ERC1 primary antibodies
  • Description
    Rabbit polyclonal to ERC1
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Dog, Turkey, Chimpanzee, Rhesus monkey, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region between residues 1000 and 1050 of Human ERC1 (NP_829884.1).

  • Positive control
    • HeLa and 293T whole cell lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab95891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 128 kDa.
IP Use at 2-5 µg/mg of lysate.

Target

  • FunctionRegulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
  • Tissue specificityWidely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
  • Involvement in diseaseThyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving ERC1/RAB6IP2 is found in cause of thyroid papillary carcinomas. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
  • Sequence similaritiesContains 1 FIP-RBD domain.
  • Cellular localizationCytoplasm. Membrane. Golgi apparatus membrane. In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cast 2 antibody
    • CAST2 antibody
    • CAZ associated structural protein 2 antibody
    • Elks antibody
    • ELKS/RAB6 interacting/CAST family member 1 antibody
    • ELKS/RAB6-interacting/CAST family member 1 antibody
    • ERC 1 antibody
    • ERC protein 1 antibody
    • ERC-1 antibody
    • Erc1 antibody
    • ERC1 protein antibody
    • KIAA1081 antibody
    • MGC12974 antibody
    • RAB6 interacting protein 2 antibody
    • RAB6-interacting protein 2 antibody
    • RAB6IP2 antibody
    • RB6I2_HUMAN antibody
    see all

Anti-ERC1 antibody images

  • All lanes : Anti-ERC1 antibody (ab95891) at 0.04 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 5 µg
    Lane 4 : 293T whole cell lysate at 50 µg


    Predicted band size : 128 kDa


    Exposure time : 10 seconds
  • Detection of ERC1 by Western Blot of Immunprecipitate.
    ab95891 at 1µg/ml staining ERC1 in HeLa whole cell lysate immunoprecipitated using ab95891 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Detection: Chemiluminescence with exposure time of 3 seonds.

References for Anti-ERC1 antibody (ab95891)

ab95891 has not yet been referenced specifically in any publications.

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