ERK2 peptide (9-19) (ab45662)

General Info

• Alternative names
  • ERK
  • ERK 2
  • ERK-2

  • ERT1
  • Extracellular Signal Regulated Kinase 2
  • Extracellular signal-regulated kinase 2
  • MAP kinase 1
  • MAP kinase 2
  • MAP kinase isoform p42
  • MAPK 1
  • MAPK 2
  • Mapk1
  • MAPK2
  • Mitogen-activated protein kinase 1
  • Mitogen-activated protein kinase 2
  • MK01_HUMAN
  • P38
  • P40
  • P41
  • p42-MAPK
  • P42MAPK
  • PRKM1
  • PRKM2
  • protein kinase, mitogen-activated, 1
  • protein kinase, mitogen-activated, 2
  • protein tyrosine kinase ERK2

  see all
• Function
  Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
  Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
• Sequence similarities
  Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
  Contains 1 protein kinase domain.
• Domain
  The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
• Post-translational
  modifications
  Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession P28482 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt