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Alternative names
- ERT1
- Extracellular Signal Regulated Kinase 2
- Extracellular signal-regulated kinase 2
- MAP kinase 1
- MAP kinase 2
- MAP kinase isoform p42
- MAPK 1
- MAPK 2
- Mapk1
- MAPK2
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 2
- MK01_HUMAN
- P38
- P40
- P41
- p42-MAPK
- P42MAPK
- PRKM1
- PRKM2
- protein kinase, mitogen-activated, 1
- protein kinase, mitogen-activated, 2
- protein tyrosine kinase ERK2
see all
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Function
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
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Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.
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Domain
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
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Post-translational
modifications
Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187.
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Cellular localization
Nucleus.
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Information by UniProt