Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab50272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 0.4 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).

Target

  • Function
    Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
  • Sequence similarities
    Belongs to the MIG6 family.
  • Domain
    The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer.
  • Cellular localization
    Cytoplasm. Cell membrane. Nucleus. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
  • Information by UniProt
  • Database links
  • Alternative names
    • ERBB receptor feedback inhibitor 1 antibody
    • ERRFI_HUMAN antibody
    • Errfi1 antibody
    • GENE 33 antibody
    • Gene 33, rat, homolog of antibody
    • Mig-6 antibody
    • MIG6 antibody
    • mitogen inducible gene 6 antibody
    • mitogen inducible gene 6 protein antibody
    • Mitogen-inducible gene 6 protein antibody
    • RALT antibody
    • receptor-associated late transducer antibody
    see all

References for Anti-ERRFI1 antibody (ab50272)

ab50272 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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