Overview

  • Product nameAnti-ERV31 antibody
    See all ERV31 primary antibodies
  • Description
    Rabbit polyclonal to ERV31
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 444-474 of Human ERV31 (NP_001007254.2).

  • Positive control
    • 293 and HepG2 cell line lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab116723 is purified through a Protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab116723 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 68 kDa.

Target

  • FunctionRetroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.
    SU mediates receptor recognition.
    TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
  • Tissue specificityExpressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea.
  • Sequence similaritiesBelongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily.
  • Developmental stageHighly expressed in primitive adrenal cortex and placenta. Expressed at lower level in developing nervous tissues, tongue, heart, gut, kidney, columna vertebralis and liver.
  • DomainContains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
  • Post-translational
    modifications
    Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). Has been mainly detected in vivo as an 65 kDa unprocessed polyprotein precursor.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • Cellular localizationVirion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Endogenous retroviral sequence 3 antibody
    • Endogenous retrovirus group 3 member 1 antibody
    • ENR1_HUMAN antibody
    • Envelope polyprotein antibody
    • envR antibody
    • ERV R antibody
    • ERV-3 envelope protein antibody
    • ERV-R envelope protein antibody
    • ERV3 1 envelope protein antibody
    • ERV3 antibody
    • ERV3 envelope protein antibody
    • ERV3-1 antibody
    • ERVR antibody
    • FLJ23884 antibody
    • HERV R antibody
    • HERV-R envelope protein antibody
    • HERV-R_7q21.2 provirus ancestral Env polyprotein antibody
    • HERVR antibody
    • SU antibody
    • TM antibody
    • Transmembrane protein antibody
    see all

Anti-ERV31 antibody images

  • All lanes : Anti-ERV31 antibody (ab116723) at 1/100 dilution

    Lane 1 : 293 cell line lysate
    Lane 2 : HepG2 cell line lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 68 kDa

References for Anti-ERV31 antibody (ab116723)

This product has been referenced in:

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"