Overview

  • Product name
  • Description
    Rabbit polyclonal to ESRP2
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant protein fragment, corresponding to a region within amino acids 107-322 of Human ESRP2 (Uniprot ID Q9H6T0)

  • Positive control
    • A431 and HepG2 cell lysates; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab155227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 78 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
  • Tissue specificity
    Epithelial cell-specific.
  • Sequence similarities
    Belongs to the ESRP family.
    Contains 3 RRM (RNA recognition motif) domains.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Epithelial splicing regulatory protein 2 antibody
    • ESRP 2 antibody
    • ESRP2 antibody
    • ESRP2_HUMAN antibody
    • FLJ21918 antibody
    • FLJ22248 antibody
    • RBM35B antibody
    • RNA binding motif protein 35A antibody
    • RNA binding motif protein 35B antibody
    • RNA binding protein 35B antibody
    • RNA-binding motif protein 35B antibody
    • RNA-binding protein 35B antibody
    see all

Images

  • All lanes : Anti-ESRP2 antibody (ab155227) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 78 kDa
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, labeling ESRP2 (green) using ab155227 at a 1/500 dilution. The slide was costained with an anti-alpha Tubulin (red).

References

ab155227 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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