Overview

  • Product nameAnti-Estrogen Receptor alpha antibody [6F11]
    See all Estrogen Receptor alpha primary antibodies
  • Description
    Mouse monoclonal [6F11] to Estrogen Receptor alpha
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human Estrogen Receptor alpha.

  • Positive control
    • Breast carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab93021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent dilution.

Target

  • FunctionNuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Post-translational
    modifications
    Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    Glycosylated; contains N-acetylglucosamine, probably O-linked.
    Ubiquitinated. Deubiquitinated by OTUB1.
    Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
    Palmitoylated (isoform 3). Not biotinylated (isoform 3).
  • Cellular localizationNucleus. Cytoplasm. Cell membrane. A minor fraction is associated with the inner membrane and Nucleus. Cytoplasm. Cell membrane. Associated with the inner membrane via palmitoylation.
  • Information by UniProt
  • Database links
  • Alternative names
    • Atherosclerosis, susceptibility to, included antibody
    • DKFZp686N23123 antibody
    • ER Alpha antibody
    • ER antibody
    • ER Beta antibody
    • ER-alpha antibody
    • ER[a] antibody
    • ER[b] antibody
    • Era antibody
    • ERalpha antibody
    • Erb antibody
    • Erb2 antibody
    • ERbeta antibody
    • ESR antibody
    • ESR BETA antibody
    • ESR1 antibody
    • ESR1_HUMAN antibody
    • ESR2 antibody
    • ESRA antibody
    • ESRB antibody
    • Estr antibody
    • Estra antibody
    • Estradiol Receptor alpha antibody
    • Estradiol receptor antibody
    • Estradiol Receptor beta antibody
    • ESTRB antibody
    • Estrogen nuclear receptor alpha antibody
    • Estrogen receptor 1 (alpha) antibody
    • Estrogen Receptor 1 antibody
    • Estrogen receptor 2 (ER beta) antibody
    • Estrogen Receptor 2 antibody
    • Estrogen receptor 2 ER beta antibody
    • Estrogen receptor alpha antibody
    • Estrogen receptor alpha 3*,4,5,6,7*/822 isoform antibody
    • Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform antibody
    • Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform antibody
    • Estrogen receptor alpha delta 4 +49 isoform antibody
    • Estrogen receptor alpha delta 4*,5,6,7*/654 isoform antibody
    • Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform antibody
    • Estrogen receptor alpha E1 E2 1 2 antibody
    • Estrogen receptor alpha E1 N2 E2 1 2 antibody
    • Estrogen receptor antibody
    • Estrogen receptor beta 4 antibody
    • Estrogen resistance, included antibody
    • ESTRR antibody
    • HDL cholesterol, augmented response of, to hormone replacement, included antibody
    • Myocardial infarction, susceptibility to, included antibody
    • NR3A1 antibody
    • NR3A2 antibody
    • Nuclear receptor subfamily 3 group A member 1 antibody
    • Nuclear receptor subfamily 3 group A member 2 antibody
    • OTTHUMP00000017718 antibody
    • OTTHUMP00000017719 antibody
    • RNESTROR antibody
    see all

Anti-Estrogen Receptor alpha antibody [6F11] images

  • ab93021 staining Estrogen Receptor alpha in formalin-fixed, paraffin-embedded Human breast carcinoma tissue.
    Note: the nuclei of the positive cells stain very strongly, without any staining in the cytoplasm.

  • ab93021 staining Estrogen Receptor alpha in formalin-fixed, paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.

References for Anti-Estrogen Receptor alpha antibody [6F11] (ab93021)

This product has been referenced in:
  • Ibarra JA  et al. Fixation time does not affect the expression of estrogen receptor. Am J Clin Pathol 133:747-55 (2010). IHC-P ; Human . Read more (PubMed: 20395521) »
  • Gomez-Fernandez C  et al. Immunohistochemical expression of estrogen receptor in adenocarcinomas of the lung: the antibody factor. Appl Immunohistochem Mol Morphol 18:137-41 (2010). IHC-P ; Human . Read more (PubMed: 19875957) »

See all 3 Publications for this product

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