The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100. Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).
FunctionOrphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
Tissue specificityExpressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
Sequence similaritiesBelongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Developmental stageExpressed at high levels in fetal brain and also in the fetal kidney, lung and liver.
Post-translational modificationsSumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity. Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
References for Anti-Estrogen Related Receptor gamma antibody (ab82319)
This product has been referenced in:
Luo Y et al. Estrogen-related receptor ? (ERR?) regulates oxygen-dependent expression of voltage-gated potassium (K+) channels and tissue kallikrein during human trophoblast differentiation. Mol Endocrinol27:940-52 (2013).
Read more (PubMed: 23584901) »
Karamanlidis G et al. Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res106:1541-8 (2010).
Read more (PubMed: 20339121) »