Overview

  • Product name
    Anti-ESX1 antibody
  • Description
    Rabbit polyclonal to ESX1
  • Tested applications
    Suitable for: IHC-P, ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to 19 amino acids near the center of Human ESX1 (Q8N693).

  • Positive control
    • Human testis tissue; Human testis tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2.5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 44 kDa.

Target

  • Function
    May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
  • Tissue specificity
    Expressed in placenta and testis. Expressed in testicular germ cell tumors.
  • Sequence similarities
    Contains 1 homeobox DNA-binding domain.
  • Post-translational
    modifications
    Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C).
  • Cellular localization
    Cytoplasm. Nucleus. ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Epx antibody
    • ESX1 antibody
    • ESX1_HUMAN antibody
    • ESX1L antibody
    • ESXR1 antibody
    • Etx antibody
    • Extraembryonic antibody
    • Extraembryonic spermatogenesis homeobox 1 antibody
    • homeobox 1 antibody
    • Homeobox protein ESX1-C antibody
    • spermatogenesis antibody
    • Spx1 antibody
    see all

Images

  • Immunofluorescence of ESX1 in Human testis tissue with ab106614 at 20 ug/mL.

  • Lane 1 : Anti-ESX1 antibody (ab106614) at 1 µg/ml
    Lane 2 : Anti-ESX1 antibody (ab106614) at 2 µg/ml

    Lane 1 : Human testis tissue lysate
    Lane 2 : Human testis tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 44 kDa
  • ab106614, at 2.5 µg/ml, staining ESX1 in paraffin embedded Human testis tissue by Immunohistochemistry.

References

ab106614 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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