Overview

  • Product name
  • Description
    Goat polyclonal to ETFA
  • Specificity
    ab104943 is expected to recognize both reported isoforms (NP_000117.1; NP_001121188.1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog, Pig, Xenopus laevis
  • Immunogen

    Synthetic peptide:

    C-QVADYGIVADLFK

    , corresponding to C terminal amino acids 309-321 of Human ETFA (NP_000117.1).

  • Positive control
    • Human, Mouse and Rat Heart lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab104943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.05 - 0.2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 35 kDa).

Target

  • Function
    The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
  • Involvement in disease
    Glutaric aciduria 2A
  • Sequence similarities
    Belongs to the ETF alpha-subunit/FixB family.
  • Domain
    Domain I shares an identical polypeptide fold with the beta subunit ETFB though there is no sequence similarity.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha ETF antibody
    • Alpha-ETF antibody
    • Electron transfer flavoprotein alpha polypeptide antibody
    • Electron transfer flavoprotein alpha subunit antibody
    • Electron transfer flavoprotein subunit alpha mitochondrial antibody
    • Electron transfer flavoprotein subunit alpha, mitochondrial antibody
    • Electron transferring flavoprotein alpha polypeptide antibody
    • EMA antibody
    • ETFA antibody
    • ETFA_HUMAN antibody
    • GA2 antibody
    • Glutaric aciduria II antibody
    see all

Images

  • Anti-ETFA antibody (ab104943) at 0.1 µg/ml + Human Heart lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 35 kDa

References

ab104943 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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