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Products:Signal Transduction >> Metabolism >> Mitochondrial
Overview
Product name
Anti-ETFA antibody
See all ETFA products (4) ...
Description
Rabbit polyclonal to ETFA
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
A synthetic peptide from the internal sequence of human ETFA (NM_000126).
Positive control
Human fetal stomach tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 2% BSA
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified by peptide affinity column.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Metabolism >> Mitochondrial
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETFA antibody (ab85150)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab85150 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
IHC-P
Application notes
IHC-P: 1/50 - 1/200.
Peptide ELISA: 1/1000 - 1/10000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
Involvement in disease
Defects in ETFA are the cause of glutaric aciduria type 2A (GA2A) [MIM:231680]; also known as glutaricaciduria IIA. GA2A is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.
Sequence similarities
Belongs to the ETF alpha-subunit/fixB family.
Post-translational
modifications
The N-terminus is blocked.
Cellular localization
Mitochondrion matrix.
Target information above from: UniProt accessionP13804
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Alpha ETF antibody
- Alpha-ETF antibody
- Electron transfer flavoprotein alpha polypeptide antibody
see all
Database links
- Entrez Gene: 2108 Human
- Entrez Gene: 110842 Mouse
- Entrez Gene: 300726 Rat
- Omim: 608053 Human
- SwissProt: P13804 Human
- SwissProt: Q99LC5 Mouse
- SwissProt: P13803 Rat
- Unigene: 39925 Human
see all
Anti-ETFA antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETFA antibody (ab85150)
ab85150, at a 1/100 dilution, staining ETFA in human fetal stomach tissue.
References for Anti-ETFA antibody (ab85150)
ab85150 has not yet been referenced specifically in any publications.
Publishing research using ab85150? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"