Overview

  • Product nameAnti-ETHE1 antibody
    See all ETHE1 primary antibodies
  • Description
    Rabbit polyclonal to ETHE1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 92-141 (RSLLPGCQSV ISRLSGAQAD LHIEDGDSIR FGRFALETRA SPGHTPGCVT) of Human ETHE1 (NP_055112).

  • Positive control
    • COLO205 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab108138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionProbably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseDefects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) [MIM:602473]. EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria.
  • Sequence similaritiesBelongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • Cellular localizationCytoplasm. Nucleus. Mitochondrion matrix. According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ethe1 antibody
    • ETHE1 protein, mitochondrial precursor antibody
    • ETHE1_HUMAN antibody
    • ethylmalonic encephalopathy 1 antibody
    • Ethylmalonic encephalopathy protein 1 antibody
    • hepatoma subtracted clone one antibody
    • Hepatoma subtracted clone one protein antibody
    • HSCO antibody
    • mitochondrial antibody
    • Protein ETHE1 antibody
    • Protein ETHE1 mitochondrial antibody
    • YF13H12 antibody
    see all

Anti-ETHE1 antibody images

  • Anti-ETHE1 antibody (ab108138) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Predicted band size : 28 kDa

References for Anti-ETHE1 antibody (ab108138)

ab108138 has not yet been referenced specifically in any publications.

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