Overview

  • Product name
  • Description
    Rabbit polyclonal to ETHE1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-204 of Human ETHE1 (UniProt O95571).

  • Positive control
    • HepG2 whole cell lysate; Human Hepatoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab126166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.
  • Tissue specificity
    Ubiquitously expressed.
  • Involvement in disease
    Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) [MIM:602473]. EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria.
  • Sequence similarities
    Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • Cellular localization
    Cytoplasm. Nucleus. Mitochondrion matrix. According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ethe1 antibody
    • ETHE1 protein, mitochondrial precursor antibody
    • ETHE1_HUMAN antibody
    • ethylmalonic encephalopathy 1 antibody
    • Ethylmalonic encephalopathy protein 1 antibody
    • hepatoma subtracted clone one antibody
    • Hepatoma subtracted clone one protein antibody
    • HSCO antibody
    • mitochondrial antibody
    • Protein ETHE1 antibody
    • Protein ETHE1 mitochondrial antibody
    • YF13H12 antibody
    see all

Images

  • Anti-ETHE1 antibody (ab126166) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 28 kDa
  • ab126166, at 1/500 dilution, staining ETHE1 in paraffin-embedded Human Hepatoma tissue by Immunohistochemistry.

References

ab126166 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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