Biological descriptionSelective and highly potent D2-like receptor antagonist (Ki values are 0.09, 0.16 and >10000 nM at D2, D3 and D1 like receptors, respectively). Shows antipsychotic activity.
Chemical name(S)-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Eticlopride hydrochloride (ab120602)
This product has been referenced in:
Martelle JL & Nader MA A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride. CNS Neurosci Ther14:248-62 (2008).
Read more (PubMed: 18801115) »
Claytor R et al. The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol Biochem Behav83:456-64 (2006).
Read more (PubMed: 16631246) »
Blokland A et al. Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats. Behav Pharmacol16:93-100 (2005).
Read more (PubMed: 15767844) »