Overview

  • Product name
    Etomidate
  • Description
    GABAA agonist
  • Biological description
    Agonist at GABAA receptors containing β3 subunits. Anaesthetic and amnesic properties.
  • Purity
    > 98%

Properties

Applications

Our Abpromise guarantee covers the use of ab120311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab7977 staining BAX in RAW 264.7 cells treated with etomidate (ab120311), by ICC/IF. Increase in BAX expression correlates with increased concentration of etomidate, as described in literature.
    The cells were incubated at 37°C for 24h in media containing different concentrations of ab120311 (etomidate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:
  • Drexler B  et al. Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology 57:446-55 (2009). Read more (PubMed: 19555700) »
  • Vanlersberghe C & Camu F Etomidate and other non-barbiturates. Handb Exp Pharmacol :267-82 (2008). Read more (PubMed: 18175096) »
  • van den Burg EH  et al. Etomidate reduces initiation of backpropagating dendritic action potentials: implications for sensory processing and synaptic plasticity during anesthesia. J Neurophysiol 97:2373-84 (2007). Read more (PubMed: 17202233) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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