Overview

  • Product nameAnti-EVC2 antibody
    See all EVC2 primary antibodies
  • Description
    Goat polyclonal to EVC2
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-LNAKKAMRALGMD

    , corresponding to C terminal amino acids 1296-1308 of Human EVC2.

  • Positive control
    • Human placenta and testis tissues

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab113924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • RelevanceEVC2 is an integral membrane protein that plays a vital role in bone formation and skeletal development. Defects in EVC2 are a cause of Ellis-van Creveld syndrome (EVC), also known as chondroectodermal dysplasia. EVC is an autosomal recessive disorder characterized by the clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia and cardiac anomalies. Patients manifest short-limb dwarfism, short ribs, postaxial polydactyly and dysplastic nails and teeth. Congenital heart defects, most commonly an atrioventricular septal defect, are observed in 60% of affected individuals. Defects in Defects in EVC2 are also a cause of acrofacial dysostosis Weyers type (WAD), also known as Curry-Hall syndrome. Acrofacial dysostoses are a heterogeneous group of disorders combining limb defects with facial abnormalities. WAD is an autosomal dominant disorder characterized by dysplastic nails, postaxial polydactyly, acrofacial dysostosis, short limbs and short stature. The phenotype is milder than Ellis-van Creveld syndrome.
  • Cellular localizationMembrane; Multi-pass membrane protein
  • Database links
  • Alternative names
    • Ellis van Creveld syndrome 2 antibody
    • LBN antibody
    • Limbin antibody

Anti-EVC2 antibody images

  • ab113924, at 3.75 µg/ml, staining EVC2 in formalin fixed, paraffin embedded Human placenta tissue by Immunohistochemistry.
  • ab113924, at 3.75 µg/ml, staining EVC2 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.

References for Anti-EVC2 antibody (ab113924)

ab113924 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113924.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"