Anti-EVC2 antibody (ab198930)
Key features and details
- Rabbit polyclonal to EVC2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-EVC2 antibody
See all EVC2 primary antibodies -
Description
Rabbit polyclonal to EVC2 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Human EVC2 (internal sequence). Gene Accession: NP_667338
Database link: Q86UK5 -
Positive control
- Lysate from human placenta tissue; Human colon cancer tissue.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198930 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/200 - 1/1000. Predicted molecular weight: 148 kDa.
|
|
IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
|
Notes |
---|
WB
1/200 - 1/1000. Predicted molecular weight: 148 kDa. |
IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
-
Function
Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development. -
Tissue specificity
Found in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. -
Involvement in disease
Ellis-van Creveld syndrome
Acrofacial dysostosis, Weyers type -
Cellular localization
Cell membrane. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane. Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 132884 Human
- Entrez Gene: 68525 Mouse
- Omim: 607261 Human
- SwissProt: Q86UK5 Human
- SwissProt: Q8K1G2 Mouse
- Unigene: 87306 Human
- Unigene: 25506 Mouse
-
Alternative names
- Ellis van Creveld syndrome 2 antibody
- Ellis-van Creveld syndrome protein 2 antibody
- EVC2 antibody
see all
Images
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (1)
ab198930 has been referenced in 1 publication.
- Estrada-Cuzcano A et al. Novel IQCE variations confirm its role in postaxial polydactyly and cause ciliary defect phenotype in zebrafish. Hum Mutat 41:240-254 (2020). PubMed: 31549751