The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesPeptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/16000.
IHC-P: Use at a concentration of 5 - 10 µg/ml.
WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 74 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionComponent of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion.
Sequence similaritiesBelongs to the EXO70 family.
DomainThe N-terminus is involved in SEC8 and ARHQ binding. The C-terminus is required for translocation to the plasma membrane.
Cellular localizationCytoplasm > cytosol. Cell membrane. Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human adrenal gland tissue, using ab77352 at 5µg/ml. Note the staining of cytoplasm membranes and cytoplasm of secretory cells in the medulla.
References for Anti-EXOC7 antibody (ab77352)
has not yet been referenced specifically in any publications.
Publishing research using ab77352? Please let us know so that we can cite the reference in this datasheet.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"