• Product nameAnti-EXOSC1 antibody
    See all EXOSC1 primary antibodies
  • Description
    Mouse polyclonal to EXOSC1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human)


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab67011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 28 kDa (predicted molecular weight: 22 kDa).


  • FunctionNon-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
  • Sequence similaritiesContains 1 S1 motif domain.
  • Cellular localizationNucleus > nucleolus. Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3'-5' exoribonuclease CSL4 homolog antibody
    • CGI 108 antibody
    • CGI-108 antibody
    • CSL4 antibody
    • CSL4 exosomal core protein homolog antibody
    • CSL4, S. cerevisiae, homolog of antibody
    • Csl4p antibody
    • EXOS1_HUMAN antibody
    • Exosc1 antibody
    • Exosomal core protein CSL4 antibody
    • Exosome complex component csl4 antibody
    • Exosome component 1 antibody
    • hCsl4p antibody
    • Homolog of yeast exosomal core protein CSL4 antibody
    • p13 antibody
    • RP11-452K12.9 antibody
    • SKI4 antibody
    • Ski4p antibody
    see all

Anti-EXOSC1 antibody images

  • All lanes : Anti-EXOSC1 antibody (ab67011) at 1/1000 dilution

    Lane 1 : EXOSC1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Predicted band size : 22 kDa
    Observed band size : 28 kDa (why is the actual band size different from the predicted?)

References for Anti-EXOSC1 antibody (ab67011)

ab67011 has not yet been referenced specifically in any publications.

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