Overview

  • Product nameAnti-Ext2 antibody
    See all Ext2 primary antibodies
  • Description
    Mouse monoclonal to Ext2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment: GFSTWTYRQG YDVSIPVYSP LSAEVDLPEK GPGPRQYFLL SSQVGLHPEY REDLEALQVK HGESVLVLDK CTNLSEGVLS VRKRCHKHQV FDYPQVLQEA , corresponding to amino acids 216-315 of Human Ext2

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab54711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionGlycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
    • Tissue specificityUbiquitous.
    • PathwayProtein modification; protein glycosylation.
    • Involvement in diseaseDefects in EXT2 are a cause of hereditary multiple exostoses type 2 (EXT2) [MIM:133701]. EXT is a genetically heterogeneous bone disorder caused by genes segregating on human chromosomes 8, 11, and 19 and designated EXT1, EXT2 and EXT3 respectively. EXT is a dominantly inherited skeletal disorder primarily affecting endochondral bone during growth. The disease is characterized by formation of numerous cartilage-capped, benign bone tumors (osteocartilaginous exostoses or osteochondromas) that are often accompanied by skeletal deformities and short stature. In a small percentage of cases exostoses have exhibited malignant transformation resulting in an osteosarcoma or chondrosarcoma. Osteochondromas development can also occur as a sporadic event.
      Defects in EXT2 are the cause of Potocki-Shaffer syndrome (PSS) [MIM:601224]. It is a contiguous gene syndrome due to proximal deletion of chromosome 11p11.2, including EXT2 and ALX4.
    • Sequence similaritiesBelongs to the glycosyltransferase 47 family.
    • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus membrane. The EXT1/EXT2 complex is localized in the Golgi apparatus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Exostoses (multiple) 2 antibody
      • Exostosin 2 antibody
      • Exostosin-2 antibody
      • EXT2 antibody
      • EXT2_HUMAN antibody
      • Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase antibody
      • Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody
      • Multiple exostoses protein 2 antibody
      • N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase antibody
      • Putative tumor suppressor protein EXT2 antibody
      • SOTV antibody
      see all

    Anti-Ext2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab54711 Ext2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-Ext2 antibody (ab54711)

    ab54711 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab54711.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"