Anti-Extracellular matrix protein 1 antibody [0.N.556] (ab17377)

Overview

  • Product nameAnti-Extracellular matrix protein 1 antibody [0.N.556]
    See all Extracellular matrix protein 1 primary antibodies
  • Description
    Mouse monoclonal [0.N.556] to Extracellular matrix protein 1
  • SpecificityAb17377 recognizes a human glycoprotein, identified as secretory component. Reacts with both free and polymeric Ig-bound secretory component. Shows no reaction in Western Blots of cell lines lacking secretory component.
  • Tested applicationsSuitable for: IHC-P, IHC-Fr, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length protein corresponding to Human Secretory Component Glycoprotein. Semi-purified human secretory component

  • Positive control
    • Small intestine, stomach, colon carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab17377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 1 µg/ml.
ICC/IF Use at an assay dependent concentration.

Target

  • FunctionInvolved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
  • Tissue specificityExpressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
  • Involvement in diseaseDefects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • ECM 1 antibody
    • Ecm1 antibody
    • ECM1_HUMAN antibody
    • Extracellular matrix protein 1 antibody
    • Secretory component p85 antibody
    • URBWD antibody
    see all

References for Anti-Extracellular matrix protein 1 antibody [0.N.556] (ab17377)

ab17377 has not yet been referenced specifically in any publications.

Product Wall

I have had a look at the nature of this protein: Extracellular matrix protein 1 (http://www.uniprot.org/uniprot/Q16610)

Unfortunately, I do not think it is scientifically to detect only ECM1b without detecting ECM1a.

The difference ...

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Application Western blot
Loading amount 1 µg
Gel Running Conditions Non-reduced Non-Denaturing (Native)
Sample Human Recombinant protein (293T cells)
Specification 293T cells
Username

Dr. Kye Hanafiah

Verified customer

Submitted Apr 18 2014

DISCOUNT CODES:

For Ab17377: ***
For Ab96196: ***

Expiration date: February 18, 2013

Value: $337 each

Each of these codes will give you $337 off your next order before the expiration date. To redeem this off...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"