Anti-Extracellular matrix protein 1 antibody [COMPO2], prediluted (ab75232)

Overview

  • Product nameAnti-Extracellular matrix protein 1 antibody [COMPO2], prediluted
    See all Extracellular matrix protein 1 primary antibodies
  • Description
    Mouse monoclonal [COMPO2] to Extracellular matrix protein 1, prediluted
  • Specificityab75232 Secretory Component is an epithelial transport receptor for polymeric IgA and IgM. Antibody to secretory component has been shown to be useful for identifying glandular carcinomas.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length native protein (purified) corresponding to Human Secretory Component Glycoprotein. Semi- purified human secretory component.

  • Positive control
    • Stomach, small intestine, colon carcinoma.
  • General notesClone designation COMPO2 is the same as SC-05.

Properties

Applications

Our Abpromise guarantee covers the use of ab75232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1.

Target

  • FunctionInvolved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
  • Tissue specificityExpressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
  • Involvement in diseaseDefects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • ECM 1 antibody
    • Ecm1 antibody
    • ECM1_HUMAN antibody
    • Extracellular matrix protein 1 antibody
    • Secretory component p85 antibody
    • URBWD antibody
    see all

Anti-Extracellular matrix protein 1 antibody [COMPO2], prediluted images

  • Formalin-fixed, paraffin-embedded human colon carcinoma stained with ab75232, using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

References for Anti-Extracellular matrix protein 1 antibody [COMPO2], prediluted (ab75232)

ab75232 has not yet been referenced specifically in any publications.

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