Anti-EYA4 antibody - Aminoterminal end (ab47990)

Overview

• Product name
  Anti-EYA4 antibody - Aminoterminal end
  See all EYA4 primary antibodies
• Description
  Goat polyclonal to EYA4 - Aminoterminal end

  This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

• Specificity
  This antibody is expected to recognise isoforms a, c and d (NP_004091.2, NP_742102.1 and NP_742103.1 respectively).
• Species reactivity
  
  Predicted to work with: Mouse, Human
• Immunogen

  Synthetic peptide:

  EDSQDLNEQSVKKTC

  , corresponding to N terminal amino acids 2-16 of Human EYA4

  Run BLAST with Run BLAST with

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage buffer
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris saline, pH 7.3
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Neuroscience
  • Sensory System
  • Visual system

  • Neuroscience
  • Sensory System
  • Auditory system

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Co-factors

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Transcription factors

Associated products

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

Applications

Target

• Function
  Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
• Tissue specificity
  Highly expressed in heart and skeletal muscle.
• Involvement in disease
  Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
• Sequence similarities
  Belongs to the HAD-like hydrolase superfamily. EYA family.
• Cellular localization
  Cytoplasm. Nucleus.

• Target information above from: UniProt accession O95677 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 2070 Human
  • Entrez Gene: 14051 Mouse
  • Omim: 603550 Human
  • SwissProt: O95677 Human
  • SwissProt: Q9Z191 Mouse
  • Unigene: 596680 Human
  • Unigene: 332128 Mouse
  • Unigene: 446298 Mouse
• Alternative names
  • CMD1J antibody
  • Deafness, autosomal dominant 10 antibody
  • DFNA 10 antibody

  • DFNA10 antibody
  • dJ78N10.1 (eyes absent (Drosophila) homolog 4) antibody
  • dJ78N10.1 (eyes absent) antibody
  • EYA 4 antibody
  • eya4 antibody
  • EYA4_HUMAN antibody
  • Eyes absent 4 antibody
  • Eyes absent homolog 4 (Drosophila) antibody
  • Eyes absent homolog 4 antibody
  • HGNC:3522 antibody
  • OTTHUMP00000040267 antibody

  see all