Overview

  • Product nameAnti-F Box G - Domain 3 antibody
    See all F Box G - Domain 3 primary antibodies
  • Description
    Rabbit polyclonal to F Box G - Domain 3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (CCYVSRRLSQ LSSHDPLWRR HCKKYWLISE EEKTQKNQCW KSLFIDTYSD) of Human FF Box G – Domain 3 protein (NP_208385).

  • Positive control
    • Human fetal small intestine lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionSubstrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • Sequence similaritiesContains 1 apaG domain.
    Contains 1 F-box domain.
  • Cellular localizationNucleus. Colocalizes with PML at the peripheries of nuclear bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • F box only protein 3 antibody
    • F box protein 3 antibody
    • F box protein FBX3 antibody
    • F-box only protein 3 antibody
    • FBA antibody
    • FBX3 antibody
    • FBX3_HUMAN antibody
    • FBXO3 antibody
    see all

Anti-F Box G - Domain 3 antibody images

  • Anti-F Box G - Domain 3 antibody (ab90143) at 1 µg/ml + Human fetal small intestine lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 55 kDa

References for Anti-F Box G - Domain 3 antibody (ab90143)

ab90143 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"