Overview

  • Product nameAnti-FA2H antibody
    See all FA2H primary antibodies
  • Description
    Rabbit polyclonal to FA2H
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C-terminal amino acids 257-306 (HGQHHKAPFD GSRLVFPPVP ASLVIAFFYV FLRLILPETV GGIIFAGGLL) of Mouse FA2H (NP_835187).

  • Positive control
    • Mouse liver lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab111554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 43 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionRequired for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids.
  • Tissue specificityDetected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
  • Involvement in diseaseDefects in FA2H are the cause of leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia (DLDSP) [MIM:612443]. The disorder consists of a progressive neurologic disease manifested by spasticity, disordered tonicity of muscle, and white matter degeneration.
    Defects in FA2H are a cause of spastic paraplegia autosomal recessive type 35 (SPG35) [MIM:612319]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
  • Sequence similaritiesBelongs to the sterol desaturase family. SCS7 subfamily.
    Contains 1 cytochrome b5 heme-binding domain.
  • DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
  • Cellular localizationEndoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FA2H antibody
    • FA2H_HUMAN antibody
    • FAAH antibody
    • FAH1 antibody
    • Fatty acid 2 hydroxylase antibody
    • Fatty acid 2-hydroxylase antibody
    • Fatty acid alpha hydroxylase antibody
    • Fatty acid alpha-hydroxylase antibody
    • Fatty acid hydroxylase domain containing 1 antibody
    • FAXDC1 antibody
    • FLJ25287 antibody
    • SCS7 antibody
    • Spastic paraplegia 35 (autosomal recessive) antibody
    • SPG35 antibody
    see all

Anti-FA2H antibody images

  • Anti-FA2H antibody (ab111554) at 1 µg/ml + Mouse liver lysate at 10 µg

    Predicted band size : 43 kDa

References for Anti-FA2H antibody (ab111554)

ab111554 has not yet been referenced specifically in any publications.

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