Overview

  • Product name
    Anti-Factor I antibody [3D6]
    See all Factor I primary antibodies
  • Description
    Mouse monoclonal [3D6] to Factor I
  • Specificity
    ab52244 is specific for the a-chain of human factor I
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Factor I isolated from human plasma

  • Positive control
    • Normal human plasma

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 0.5M Sodium chloride, 10mM PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    3D6
  • Myeloma
    x63-Ag8.653
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab52244 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Use under non reducing condition. Predicted molecular weight: 65 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
  • Tissue specificity
    Plasma.
  • Involvement in disease
    Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3) [MIM:612923]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
    Defects in CFI are the cause of complement factor I deficiency (CFI deficiency) [MIM:610984]. CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 1 Kazal-like domain.
    Contains 2 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • Cellular localization
    Secreted > extracellular space.
  • Information by UniProt
  • Database links
  • Alternative names
    • AHUS3 antibody
    • ARMD13 antibody
    • C3b INA antibody
    • C3b inactivator antibody
    • C3B/C4B inactivator antibody
    • C3BINA antibody
    • CFAI_HUMAN antibody
    • Cfi antibody
    • Complement component I antibody
    • Complement control protein factor I antibody
    • Complement factor I antibody
    • Complement factor I heavy chain antibody
    • Complement factor I light chain antibody
    • F1 antibody
    • factor I antibody
    • FactorI antibody
    • FI antibody
    • I factor antibody
    • IF antibody
    • KAF antibody
    • Konglutinogen activating factor antibody
    • Light chain of factor I antibody
    • OTTHUMP00000219728 antibody
    • OTTHUMP00000221928 antibody
    see all

References

ab52244 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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